| 產(chǎn)品編號(hào) | bsm-0514M-AP |
| 英文名稱1 | Mouse Anti-BMP2/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的骨形態(tài)發(fā)生蛋白2抗體 |
| 別 名 | bone morphogenetic protein 2; BMP 2; BMP 2A; BMP2; BMP2A; BMP-2; BMP2_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 生長(zhǎng)因子和激素 |
| 抗體來(lái)源 | Mouse |
| 克隆類(lèi)型 | Monoclonal |
| 交叉反應(yīng) | (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 13/44kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human BMP2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis. Function: Induces cartilage and bone formation. Subunit: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN. Subcellular Location: Secreted. Tissue Specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine. Similarity: Belongs to the TGF-beta family. Database links: Entrez Gene: 650 Human Entrez Gene: 12156 Mouse Omim: 112261 Human SwissProt: P12643 Human SwissProt: P21274 Mouse Unigene: 73853 Human Unigene: 103205 Mouse Unigene: 90931 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)干細(xì)胞標(biāo)志物 BMP-2主要對(duì)未分化間充質(zhì)細(xì)胞和骨系細(xì)胞起到募集和分化作用。在骨形成早期，BMP-2不僅可使未分化間質(zhì)細(xì)胞向骨形成中心募集，并分化為骨系細(xì)胞，而且可使成纖維細(xì)胞、成肌細(xì)胞及骨髓的基細(xì)胞逆轉(zhuǎn)分化為骨系細(xì)胞。其主要過(guò)程是：增加或抑制這些細(xì)胞內(nèi)的某些特異性蛋白的分泌，使成纖維細(xì)胞分化為成骨細(xì)胞，成肌細(xì)胞快速分化為肥大的軟骨細(xì)胞，并促進(jìn)基質(zhì)鈣化。 對(duì)于成骨細(xì)胞，BMP-2則可使之維持其特有細(xì)胞表型，并誘導(dǎo)成骨細(xì)胞標(biāo)志物的增高，促進(jìn)細(xì)胞外基質(zhì)鈣化。在骨形成后期，BMP-2還作為一種破骨細(xì)胞分化因子與其它支持破骨細(xì)胞分化因子直接或間接刺激破骨細(xì)胞分化，參與骨的重建。 |
