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Mouse Anti-ERCC1/PE-Cy7 Conjugated antibody (bsm-33084M-PE-Cy7)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bsm-33084M-PE-Cy7
英文名稱1 Mouse Anti-ERCC1/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的DNA切除修復(fù)蛋白1抗體
別    名 Excision Repair Cross Complementing 1; DNA excision repair protein ERCC-1; COFS4; UV20; DNA excision repair protein ERCC1; ERCC 1; Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1; Excision repair protein; UV 20; UV20;DNA excision repair protein ERCC-1.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  
抗體來(lái)源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) 3C11
交叉反應(yīng)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ERCC1
亞    型 IgG
純化方法 affinity purified by Protein G
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

Subunit:
Heterodimer composed of ERCC1 and XPF/ERRC4.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the ERCC1/RAD10/SWI10 family.

Database links:

Entrez Gene: 2067 Human

Entrez Gene: 13870 Mouse

Entrez Gene: 292673 Rat

Omim: 126380 Human

SwissProt: P07992 Human

SwissProt: P07903 Mouse

Unigene: 435981 Human

Unigene: 280913 Mouse

Unigene: 7320 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ERCC1蛋白是動(dòng)物內(nèi)重要的DNA修復(fù)基因家族成員之一。在人體內(nèi)它的低表達(dá)往往伴隨著基因不穩(wěn)定性增加,從而產(chǎn)生腫瘤惡性變的發(fā)生。ERCC1是損傷DNA核苷酸切除修復(fù)中高度保守的切除性核酶。在哺乳動(dòng)物的核苷酸切除修復(fù)中,XPG負(fù)責(zé)切割DNA損傷區(qū)域的3’端,而ERCC1-XPF復(fù)合物在5’端打開(kāi)切口。目前初步的研究表明,癌瘤中的ERCC1蛋白表達(dá)程度越低,順氯氨鉑化療的效果就越好。ERCC1蛋白陽(yáng)性的患者,非化療治療的預(yù)后要好于接受化療。
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