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Rabbit Anti-FGF2  antibody (bs-0217R)  
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產(chǎn)品編號(hào) bs-0217R
英文名稱 Rabbit Anti-FGF2  antibody
中文名稱 堿性成纖維細(xì)胞生長(zhǎng)因子/FGF2抗體
別    名 Basic fibroblast growth factor; FGF basic; FGF-basic; BFGF; FGF-2; FGF B; FGF2 basic; FGFB; Fibroblast growth factor 2 (basic); HBGF 2; HBGF-2; HBGF2; HBGH 2; HBGH2; Heparin binding growth factor 2 precursor; Prostatropin; FGF2_HUMAN.  
Specific References  (32)     |     bs-0217R has been referenced in 32 publications.
[IF=7.991] Xiangfeng Li. et al. Design of macropore structure and micro-nano topography to promote the early neovascularization and osteoinductivity of biphasic calcium phosphate bioceramics. Mater Design. 2022 Apr;216:110581  IF ;  Human.  
[IF=6.832] Liu, Jingyu. et al. Therapeutic effect of adipose stromal vascular fraction spheroids for partial bladder outlet obstruction induced underactive bladder. Stem Cell Res Ther. 2022 Dec;13(1):1-16  WB ;  Rat.  
[IF=6.633] Anna Krzy?ewska. et al. Cannabidiol alleviates right ventricular fibrosis by inhibiting the transforming growth factor β pathway in monocrotaline-induced pulmonary hypertension in rats. BBA-MOL BASIS DIS. 2023 Aug;1869:166753  IHC ;  Rat.  
[IF=5.62] He, Ting, et al. "Tumor cell-secreted angiogenin induces angiogenic activity of endothelial cells by suppressing miR-542-3p." Cancer Letters (2015).  WB ;  Human.  
[IF=5.396] Ali Bagherian. et al. Anti-glioblastoma effects of nanomicelle-curcumin plus erlotinib. Food Funct. 2021 Oct;:  WB ;  Human.  
[IF=5.396] Wenji Hu. et al. Structural characterization of polysaccharide purified from Amanita caesarea and its pharmacological basis for application in Alzheimer's disease: endoplasmic reticulum stress. Food Funct. 2021 Oct;:  WB ;  Human.  
[IF=5.097] Yan L et al. Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity. Cell Biology and Toxicology.  WB ;  Human.  
[IF=4.929] Zhou L et al.Protective Effects of Uncultured Adipose‐Derived Stromal Vascular Fraction on Testicular Injury Induced by Torsion‐Detorsion in Rats. (2018) Stem Cells Translational Medicine  WB ;  Rat.  
[IF=4.889] Fengchun Liao. et al. ECFC-derived exosomal THBS1 mediates angiogenesis and osteogenesis in distraction osteogenesis via the PI3K/AKT/ERK pathway. J ORTHOP TRANSL. 2022 Nov;37:12  WB ;  Human.  
[IF=4.65] Pan, Ruo-Lang, et al. "Delta-like 1 serves as a new target and contributor to liver fibrosis down-regulated by mesenchymal stem cell transplantation." Journal of Biological Chemistry 286.14 (2011): 12340-12348.  Mouse.  
[IF=4.379] Zhou, Liuhua. et al. Effect of uncultured adipose-derived stromal vascular fraction on preventing urethral stricture formation in rats. Sci Rep-Uk. 2022 Mar;12(1):1-10  WB ;  Rat.  
[IF=3.571] Mei F et al. Collagen peptides isolated from Salmon salar and Tilapia nilotica skin accelerate wound healing by altering cutaneous microbiome colonization via up-regulated NOD2 and BD14. Agric. Food Chem. 2020, 68, 6, 1621-1633.  IHC-P ;  Rat.  
[IF=3.514] Liuhong Liu. et al. Experimental study on the effect of chrysin on skin injury induced by amiodarone extravasation in rats. Microvasc Res. 2022 Jan;139:104257  IHC ;  rat.  
[IF=3.49] Turgut, Burak, et al. "Topical infliximab for the suppression of wound healing following experimental glaucoma filtration surgery." Drug Design, Development and Therapy 8 (2014): 421-429.  IHC-P ;  Rabbit.  
[IF=2.959] Peng W et al.Expression of osteoprotegerin and receptor activator for the nuclear factor-κB ligand in XACB/LV-bFGF/MSCs transplantation for repair of rabbit femoral head defect necrosis.(2018) J. Cell. Biochem. Oct 18  WB ;  Rabbit.  
[IF=2.89] Liu, Kai-Jun, et al. "Analysis of olfactory ensheathing glia transplantation-induced repair of spinal cord injury by electrophysiological, behavioral, and histochemical methods in rats." Journal of molecular neuroscience 41.1 (2010): 25-29.  Human.  
[IF=2.83] Sun, Fei, et al. "Structural integrity, immunogenicity and biomechanical evaluation of rabbit decelluarized tracheal matrix." Journal of Biomedical Materials Research Part A (2014).  IHC-P ;  Rabbit.  
[IF=2.478] Liu G et al. B-cell leukemia/lymphoma 10 promotes angiogenesis in an experimental corneal neovascularization model. Eye,2018 32(7), 1220–1231.  FCM ;  Mouse.  
[IF=2.28] Liu et al. B-cell leukemia/lymphoma 10 promotes angiogenesis in an experimental corneal neovascularization model. (2018) Eye.(Lond).  FC/FACS ;  Mouse.  
[IF=2.247] Tort S et al. The effect of a new wound dressing on wound healing: Biochemical and histopathological evaluation. Burns. 2019 Dec 17. pii: S0305-4179(18)30976-8.  IHC-P ;  Rat.  
[IF=2.136] Gao XX et al. Effects of L-arginine on endometrial microvessel density in nutrient-restricted Hu sheep.Theriogenology. 2018 Oct 1;119:252-258.  IHC-P&WB ;  Sheep.  
[IF=1.994] YING-HAO HAN. et al. Peroxiredoxin II Inhibits Alcohol-induced Apoptosis in L02 Hepatocytes Through AKT/β-Catenin Signaling Pathway. Anticancer Res. 2020 Aug;40(8):4491-4504  WB ;  Human.  
[IF=1.96] Turgut, Burak, et al. "Impact of trastuzumab on wound healing in experimental glaucoma surgery." Clinical & Experimental Ophthalmology (2014).  IHC-P ;  Rabbit.  
[IF=1.94] De Nan. et al. In Vitro Study of Adipose-Derived Mesenchymal Stem Cells Transduced with Lentiviral Vector Carrying the Brain-Derived Neurotrophic Factor Gene. Int J Stem Cells. 2020; 13(3): 386–393  WB ;  Mouse.  
[IF=1.93] Lee, Hye Sook, et al. "Anti-neovascular effect of chondrocyte-derived extracellular matrix on corneal alkaline burns in rabbits." Graefes Archive for Clinical and Experimental Ophthalmology (2014): 1-11.  IHC-P ;  Rabbit.  
[IF=1.93] Chen, Bo-Yu, et al. "Altered TGF-β2 and bFGF expression in scleral desmocytes from an experimentally-induced myopia guinea pig model." Graefes Archive for Clinical and Experimental Ophthalmology (2013): 1-12.  Pig, Guinea Pig.  
[IF=1.69] Zhao, Zhan‐Zheng, et al. "Effects of recombinant human endostatin on peritoneal angiogenesis in peritoneal dialysis rats." Nephrology 16.6 (2011): 599-606.  Rat.  
[IF=1.69] Gao, Dan, et al. "Effect of peritoneal dialysis on expression of vascular endothelial growth factor, basic fibroblast growth factor and endostatin of the peritoneum in peritoneal dialysis patients." Nephrology 16.8 (2011): 736-742.  WB ;  Human.  
[IF=1.64] Eren, Kenan, et al. "The Suppression of Wound Healing Response with Sirolimus and Sunitinib Following Experimental Trabeculectomy in a Rabbit Model." Current Eye Research (2016): 1-10.  IHC-P ;  Rabbit.  
[IF=0.37] Shkurupy, V. A., et al. "In Vitro Effects of Nanosized Diamond Particles on Macrophages." Bulletin of Experimental Biology and Medicine (2015): 1-4.  Mouse.  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  免疫學(xué)  生長(zhǎng)因子和激素  細(xì)胞因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat,Rabbit,Sheep,Cow,Chicken)
產(chǎn)品應(yīng)用 WB=1:500-2000,Flow-Cyt=1μg/Test,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 18kDa
細(xì)胞定位 細(xì)胞核 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human bFGF: 143-250/288 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008].

Function:
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

Subunit:
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2.

Subcellular Location:
Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.

Tissue Specificity:
Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.

Post-translational modifications:
Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.

Similarity:
Belongs to the heparin-binding growth factors family.

SWISS:
P09038

Gene ID:
2247

Database links:

Entrez Gene: 2247 Human

Entrez Gene: 14173 Mouse

Entrez Gene: 54250 Rat

Omim: 134920 Human

SwissProt: P09038 Human

SwissProt: P15655 Mouse

SwissProt: P13109 Rat

Unigene: 284244 Human

Unigene: 473689 Mouse

Unigene: 31808 Rat



生長(zhǎng)因子和激素( Growth Factor and Hormones)

(b-FGF)主要分布于垂體、腦和神經(jīng)組織及視網(wǎng)膜、腎上腺、胎盤等,尤以垂體含量最高。
FGF2(basic fibroblast growth factor)堿性成纖維細(xì)胞生長(zhǎng)因子是由內(nèi)皮細(xì)胞及平滑肌細(xì)胞合成并對(duì)合成細(xì)胞有促分裂效應(yīng)的多肽分子,具有強(qiáng)烈的血管生成作用,參與血管生成、組織修復(fù)、神經(jīng)系統(tǒng)的發(fā)育等 。FGF2在體外,能刺激細(xì)胞增殖,細(xì)胞遷移,誘導(dǎo)纖溶酶原激活物及膠原酶活性。是能與肝素結(jié)合的促分裂劑。
FGF家族參與一系列重要的生理功能:胚胎發(fā)育、細(xì)胞生長(zhǎng)、組織的修復(fù)、器官的形成、腫瘤的浸潤(rùn)和生長(zhǎng)等。

產(chǎn)品圖片
Sample: HepG2(Human) Cell Lysate at 30 ug Primary: Anti-bFGF (bs-0217R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 18 kD Observed band size: 18 kD
Blank control (Black line): Molt4 (Black). Primary Antibody (green line): Rabbit Anti-bFGF antibody (bs-0217R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-AF647 Dilution: 1μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
Blank control:HepG2. Primary Antibody (green line): Rabbit Anti-bFGF antibody (bs-0217R) Dilution: 2μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-AF488 Dilution: 1μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at-20℃.The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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