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GLP-1R Rabbit pAb (bs-1559R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產(chǎn)品編號 bs-1559R
英文名稱 GLP-1R Rabbit pAb
中文名稱 胰高血糖素樣肽-1受體/GLP-1受體抗體
別    名 Glucagon like peptide-1 receptor; GLP 1 R; GLP 1 receptor; GLP 1R; Glp1r; GLP; glp1r; Glucagon like peptide 1 receptor; RATGL1RCP; Glip; MGC138331; GLP-1-R; GLP1R_HUMAN; Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R; Precursor.  
Specific References  (16)     |     bs-1559R has been referenced in 16 publications.
[IF=5.71] Zhou, Hao, et al. "Exendin-4 protects ADMSCs from apoptosis induced by Hydrogen peroxide through PI3K/Akt-Sfrp2 pathways." Free Radical Biology and Medicine (2014).  Rat.  
[IF=5.7] Shan Y et al. The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke. J Neuroinflammation. 2019 Nov 28;16(1):242.  IHF ;  Rat.  
[IF=5.682] Haoqiang Zhang. et al. Glucagon-like peptide-1 attenuated carboxymethyl lysine induced neuronal apoptosis via peroxisome proliferation activated receptor-γ. Aging-Us. 2021 Jul 31; 13(14): 19013–19027  WB ;  Rat.  
[IF=5.64] Yuping Chen. et al. The Herb Pair Radix Rehmanniae and Cornus Officinalis Attenuated Testicular Damage in Mice With Diabetes Mellitus Through Butyric Acid/Glucagon-Like Peptide-1/Glucagon-Like Peptide-1 Receptor Pathway Mediated by Gut Microbiota. Front Microbiol. 2022 Feb 22;13:831881  IF,WB ;  Mouse.  
[IF=5.037] Zhan-zhao Liu. et al. Glucagon-like peptide-1 receptor activation by liraglutide promotes breast cancer through NOX4/ROS/VEGF pathway. Life Sci. 2022 Apr;294:120370  WB ;  Human.  
[IF=4.013] Hongzeng Li. et al. Eugenol alleviated nonalcoholic fatty liver disease in rat via a gut-brain-liver axis involving glucagon-like Peptide-1. ARCH BIOCHEM BIOPHYS. 2022 May;:109269  WB,IF ;  Rat.  
[IF=3.841] Qiaoji Tian. et al. Glucagon-Like Peptide-1 Receptor Mediates the Improvement in Glycolipid Metabolism Disorder via AKT and AMPK Signalling Pathways in L02 Cells with Insulin Resistance. J MOL STRUCT. 2022 Oct;:134328  IHC ;  Human.  
[IF=3.647] Melek T et al. Ileal interposition improves metabolic syndrome parameters in a rat model of metabolic syndrome induced by monosodium glutamateLife Sci.2020 Dec 9;266:118846.  WB ;  Rat.  
[IF=3.469] Shuangli Yang. et al. Glucagon-like peptide-1 alleviates diabetic kidney disease through activation of autophagy by regulating AMP-activated protein kinase-mammalian target of rapamycin pathway. Am J Physiol-Endoc M. 2020 Nov;319(6):E1019-E1030  WB,IF ;  Rat.  
[IF=3.288] Kanda et al. Expression of the glucagon-like peptide-1 receptor and its role in regulating autophagy in endometrial cancer. (2018) BMC.Cancer. 18:657  WB ;  Human.  
[IF=3.124] Wu Li. et al. GLP1R inhibits the progression of endometrial carcinoma through activation of cAMP/PKA pathway. J CLIN LAB ANAL. 2022 Aug;:e24604  WB ;  Human.  
[IF=3.06] Nagai, Takuo, et al. "Linagliptin Ameliorates Methylglyoxal-Induced Peritoneal Fibrosis in Mice." PLOS ONE 11.8 (2016): e0160993.  WB, IHC-P ;  Mouse.  
[IF=2.559] Wen Y et al. Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy. Biochem Biophys Res Commun. 2019 Mar 26;511(1):79-86.  IP,WB&IHC ;  Rat&Human.  
[IF=2.395] Kim SJ et al. DPP-4 inhibition enhanced renal tubular and myocardial GLP-1 receptor expression decreased in CKD with myocardial infarction.BMC Nephrol. 2019 Mar 1;20(1):75.  WB ;  Rat.  
[IF=2.276] Liu Jinlei. et al. Emodin Attenuated the Kidney Damage of High-Fat-Diet Mice via the Upregulation of Glucagon-Like Peptide-1 Receptor. Biomed Res Int. 2021;2021:6662704  WB ;  Mouse.  
[IF=1.448] Bu?dak ? et al. The impact of exenatide (a GLP-1 agonist) on markers of inflammation and oxidative stress in normal human astrocytes subjected to various glycemic conditions. Exp Ther Med. 2019 Apr; 17(4): 2861–2869.  WB ;  Human.  
研究領(lǐng)域 免疫學(xué)  生長因子和激素  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:200-1000,IHC-F=1:200-1000,IF=1:200-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 51 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat GLP-1R: 101-200/463 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 GLP1R is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.It has been suggested that this protein influences the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. GLP1R is believed to be expressed in human pancreas,lung, brain, stomach, kidney and heart. ESTs have been isolated from skin and kidney libraries.

Function:
This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subunit:
May form homodimers and heterodimers with GIPR.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Post-translational modifications:
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.

Similarity:
Belongs to the G-protein coupled receptor 2 family.

SWISS:
P32301

Gene ID:
25051

Database links:

Entrez Gene: 2740 Human

Entrez Gene: 14652 Mouse

Entrez Gene: 25051 Rat

Omim: 138032 Human

SwissProt: P43220 Human

SwissProt: O35659 Mouse

SwissProt: P32301 Rat

Unigene: 389103 Human

Unigene: 390969 Mouse

Unigene: 11408 Rat



GLP-1R是GLP-1在體內(nèi)作用的主要靶點,它是一個7次跨膜的G蛋白偶聯(lián)受體,以cAMP為主要第二信使。GLP-1與GLP-1R結(jié)合過程是一個兩結(jié)構(gòu)域相互作用的過程,都與胰島素分泌和糖代謝調(diào)節(jié)密切相關(guān)。
產(chǎn)品圖片
Sample: Lane 1: Mouse Pancreas tissue lysates Lane 2: Mouse Liver tissue lysates( negative control) Primary: Anti-GLP-1R (bs-1559R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51 kDa Observed band
Paraformaldehyde-fixed, paraffin embedded Human Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with GLP-1R Polyclonal Antibody, Unconjugated (bs-1559R) at 1:800 overnight at 4°C, followed by conjuga
Paraformaldehyde-fixed, paraffin embedded Rat Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with GLP-1R Polyclonal Antibody, Unconjugated (bs-1559R) at 1:800 overnight at 4°C, followed by conjugati
Paraformaldehyde-fixed, paraffin embedded Mouse Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with GLP-1R Polyclonal Antibody, Unconjugated (bs-1559R) at 1:800 overnight at 4°C, followed by conjuga
(Negative control) Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with GLP-1R Polyclonal Antibody, Unconjugated (bs-1559R) at 1:800 overnight at 4°C, fol
(Negative control) Paraformaldehyde-fixed, paraffin embedded Rat Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with GLP-1R Polyclonal Antibody, Unconjugated (bs-1559R) at 1:800 overnight at 4°C, follo
(Negative control) Paraformaldehyde-fixed, paraffin embedded Mouse Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with GLP-1R Polyclonal Antibody, Unconjugated (bs-1559R) at 1:800 overnight at 4°C, fol
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