| 產(chǎn)品編號(hào) | bs-1714R |
| 英文名稱 | Rabbit Anti-Dopamine Transporter antibody |
| 中文名稱 | 多巴胺轉(zhuǎn)運(yùn)蛋白DAT抗體 |
| 別 名 | DA transporter; DAT 1; DAT; DAT1; SC6A3_HUMAN; SLC6A3; Sodium dependent dopamine transporter; Sodium-dependent dopamine transporter; Solute carrier family 6 (neurotransmitter transporter dopamine), member 3; Solute carrier family 6 member 3; Variable number tandem repeat (VNTR); dopamine transporter; ADAT 1; Adenosine deaminase tRNA specific 1; HADAT1; tRNA specific adenosine deaminase 1. |
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Specific References (10) | bs-1714R has been referenced in 10 publications.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 68kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DAT1: 579-620/620 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009] Function: Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Subunit: Homooligomer; disulfide-linked. Interacts with PRKCABP and TGFB1I1. Interacts (via N-terminus) with SYNGR3 (via N-terminus). Interacts with SLC18A2. Subcellular Location: Membrane; Multi-pass membrane protein. DISEASE: Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs. Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. SWISS: Q01959 Gene ID: 6531 Database links: Entrez Gene: 6531 Human Entrez Gene: 13162 Mouse Omim: 126455 Human SwissProt: Q01959 Human SwissProt: Q61327 Mouse Unigene: 406 Human Unigene: 41993 Mouse Unigene: 10093 Rat DATI 可能參與神經(jīng)系統(tǒng)的多種活動(dòng)，如學(xué)習(xí)記憶、嗅覺、感覺、運(yùn)動(dòng)、多巴胺神經(jīng)遞質(zhì)活動(dòng)的調(diào)節(jié)，而且可能參與膠質(zhì)瘤等神經(jīng)系統(tǒng)腫瘤的發(fā)生,陽性著色主要定位于細(xì)胞質(zhì)，但也可見到有些細(xì)胞核內(nèi)的陽性染色. |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Rat Cerebrum tissue lysates
Lane 2: Rat Liver tissue lysates(Negative control)
Primary: Anti-Dopamine Transporter (bs-1714R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 68 kDa
Observed band size: 73 kDa
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