| 產(chǎn)品編號 | bs-1997R |
| 英文名稱 | NCX2 Rabbit pAb |
| 中文名稱 | 鈉鈣交換蛋白2抗體 |
| 別 名 | SLC8A2; Sodium/calcium exchanger 2; solute carrier family 8(sodium/calcium exchanger), member 2; Na(+)/Ca(2+)-exchange protein 2; Na+/Ca2+exchanger 2; sodium/calcium exchanger 2 precursor; Slc8a2; NAC2_HUMAN; SLC8A2. |
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Specific References (4) | bs-1997R has been referenced in 4 publications.
[IF=3.457] Chen M et al.
Protective effects of echinacoside against anoxia/reperfusion injury in H9c2 cells via up-regulating p-AKT and SLC8A3.Biomed Pharmacother. 2018 Aug;104:52-59. WB ; Rat.
[IF=3.201] Zhang J et al. TRPV4 Complexes With the Na/Ca 2 Exchanger and IP 3 Receptor 1 to Regulate Local Intracellular Calcium and Tracheal Tension in Mice. Front. Physiol., 06 December 2019. Co-IP&WB ; Mouse.
[IF=2.959] Zhixiu Xia. et al. NCX3 alleviates ethanol-induced apoptosis of SK-N-SH cells via the elimination of intracellular calcium ions. Toxicol In Vitro. 2021 Apr;72:105104 WB ; Human.
[IF=1.963] Zhixiu Xia. et al. The downregulation of NCXs is positively correlated with the prognosis of stage II–IV colon cancer. World J Surg Oncol. 2021 Dec;19(1):1-14 WB,IHC ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 交換蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog,GuineaPig,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 98 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NCX2: 601-700/921 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized. Function: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. Contains 2 Calx-beta domains. Gene ID: 6543 Database links: UniProtKB/Swiss-Prot: Q9UPR5.2 鈉鈣交換蛋白又稱鈉鈣交換體，有三種同分異構(gòu)體,即NCX1、NCX2和NCX3。2型Na-Ca交換蛋白-NCX2, 很多組織中都有表達(dá)，分布與胞漿及胞膜。 |
