| 產(chǎn)品編號(hào) | bs-2470R |
| 英文名稱 | Rabbit Anti-CD244 antibody |
| 中文名稱 | CD244抗體 |
| 別 名 | NKR2B4; SLAMF4; natural killer cell receptor 2B4 isoform 2 precursor; 2B4 ; C9.1; CD244 antigen; CD244 molecule natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; F730046O15Rik; h2B4; Ly90; NAIL; Natural killer cell activation-inducing ligand; Natural killer cell receptor 2B4; NK cell activation inducing ligand; NK cell activation inducing ligand NAIL; NK cell type I receptor protein 2B4; Nmrk; Non-MHC restricted killing associated; OTTHUMP00000027884; p38; SLAM family, member 4. |
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Specific References (2) | bs-2470R has been referenced in 2 publications.
[IF=6.66] Peiffer, Daniel S., et al. "Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer." Cancer immunology research 4.1 (2016): 72-82. IHC-P ; Rat.
[IF=4.047] Xu Xiaoyan. et al. A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-α and IFN-γ production in dNK cells during Toxoplasma gondii infection. PARASITE VECTOR. 2022 Dec;15(1):1-15 WB ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 干細(xì)胞 細(xì)胞粘附分子 細(xì)胞表面分子 自然殺傷細(xì)胞 淋巴細(xì)胞 t-淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Rat (predicted: Mouse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 42kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD244: 151-250/370 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] Function: Modulate other receptor-ligand interactions to enhance leukocyte activation. Subunit: Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2. Subcellular Location: Membrane; Single-pass type I membrane protein (Potential). Tissue Specificity: Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils. Similarity: Contains 2 Ig-like (immunoglobulin-like) domains. SWISS: Q9BZW8 Gene ID: 51744 Database links: Entrez Gene: 51744 Human Entrez Gene: 18106 Mouse Omim: 605554 Human SwissProt: Q9BZW8 Human SwissProt: Q07763 Mouse Unigene: 157872 Human Unigene: 2299 Mouse Unigene: 113760 Rat Unigene: 53994 Rat |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Rat Thymus tissue lysates
Lane 2: Rat Lymph node tissue lysates
Lane 3: Human Serum
Primary: Anti-CD244 (bs-2470R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size:42 kD
Observed band size:70 kD
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