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Rabbit Anti-CD99  antibody (bs-2523R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bs-2523R
英文名稱 Rabbit Anti-CD99  antibody
中文名稱 CD99抗體
別    名 T-cell surface glycoprotein E; T cell surface glycoprotein E2 precursor; 12E7; Antigen identified by monoclonal 12E7 Y homolog; Antigen identified by monoclonal antibodies 12E7 F21 and O13; CD 99; CD99 antigen; CD99 molecule; CD99X; E2 antigen; Ewing Sarcoma; MIC 2; MIC 2X; MIC 2Y; MIC2; MIC2X; MIC2Y; Monoclonal antibody 12E7; MSK5X; Protein MIC2; Surface antigen MIC2.  
Specific References  (1)     |     bs-2523R has been referenced in 1 publications.
[IF=20.565] Aguayo-Mazzucato C et al. β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. (2017) Cell.Metab. 25:898-910.e5  IF ;  Mouse.  
研究領(lǐng)域 腫瘤  細胞生物  免疫學(xué)  細胞表面分子  糖蛋白  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Mouse,Rat)
產(chǎn)品應(yīng)用 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 16kDa
檢測分子量 32
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CD99: 45-150/175 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.

Subunit:
Homodimer. Interacts with PILRB.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Natural killer cells.

Similarity:
Belongs to the CD99 family.

SWISS:
Q8VCN6

Gene ID:
673094

Database links:

Entrez Gene: 4267 Human

Entrez Gene: 673094 Mouse

Omim: 313470 Human

SwissProt: P14209 Human

SwissProt: Q8VCN6 Mouse

Unigene: 653349 Human

Unigene: 423040 Mouse



CD99(P30/32MIC2)是一種跨膜蛋白,為MIC2基因產(chǎn)物。分布于淋巴細胞、胸腺皮質(zhì)細胞、卵巢的顆粒細胞、胰島細胞和睪丸支持細胞。
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