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Rabbit Anti-HAVCR1  antibody (bs-2713R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-2713R
英文名稱 Rabbit Anti-HAVCR1  antibody
中文名稱 腎損傷分子1/甲型肝炎病毒細胞受體1抗體
別    名 HAVCR; HAVCR 1; HA; Vcr-1; hepatitis A virus cellular receptor 1; HKIM-1; Kidney Injury Molecule1; KIM1; KIM 1; KIM-1; TIM-1; TIMD 1; TIMD1; KM-1; TIMD1_HUMAN; T cell immunoglobin domain and mucin domain protein 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell membrane protein 1.  腎臟損傷分子1
Specific References  (14)     |     bs-2713R has been referenced in 14 publications.
[IF=11.556] Wen-juan Jiang. et al. Tubular epithelial cell-to-macrophage communication forms a negative feedback loop via extracellular vesicle transfer to promote renal inflammation and apoptosis in diabetic nephropathy. Theranostics. 2022; 12(1): 324–339  WB ;  Mouse,Human.  
[IF=9.473] Xiao-yan He. et al. Cpd-42 Alleviates Acute Kidney Injury via Targeting RIPK3-mediated Necroptosis. BRIT J PHARMACOL. 2023 May;:  IHC,WB ;  Mouse.  
[IF=7.31] Huang Yue-bo. et al. Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis. OXID MED CELL LONGEV. 2022;2022:4776243  IHC, IF ;  Mouse.  
[IF=6.691] Jiang, Wenjuan. et al. Macrophage-derived, LRG1-enriched extracellular vesicles exacerbate aristolochic acid nephropathy in a TGFβR1-dependent manner. 2021 Oct 22  WB,IF ;  Mouse.  
[IF=6.304] Zhu H et al. PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cellsCell Death Dis.2020 Dec 12;11(12):1057.  IF、WB ;  Mouse.  
[IF=5.275] Ming-jun Yu. et al. Discovery of a Novel GRPR Antagonist for Protection against Cisplatin-Induced Acute Kidney Injury. BIOORG CHEM. Bioorg Chem. 2022 Apr;:105794  WB ;  Mouse,Human.  
[IF=5.085]   WB , IF ;  
[IF=5.064] Fang Wang. et al. Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis. Acta Pharmacol Sin. 2021 Apr;:1-12  WB,IF,IHC ;  Human, Mouse.  
[IF=3.448] Topda?? ? et al. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life Sci. 2020 Feb 1;242:117217.  IHC ;  Rat.  
[IF=3.292] Ademola Adetokunbo Oyagbemi. et al. Luteolin supplementation ameliorates cobalt-induced oxidative stress and inflammation by suppressing NF-кB/Kim-1 signaling in the heart and kidney of rats. Environ Toxicol Phar. 2020 Nov;80:103488  IHC ;  Rat.  
[IF=3.222] Pengmin Ji. et al. Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice. RENAL FAILURE. 2023;45(1):Article: 2197075  WB ;  Mouse.  
[IF=2.491] Oyagbemi AA et al. Ameliorative effect of Rutin on sodium fluoride‐induced hypertension through modulation of Kim‐1/NF‐κB/Nrf2 signaling pathway in rats.(2018)Environ Toxicol.  IHC ;  Rat.  
[IF=1.718] Selim ?omakl?. et al. Morin mitigates ifosfamide induced nephrotoxicity by regulation of NF-kappaB/p53 and Bcl-2 expression. 2022 Jan 17  IHC ;  Rat.  
[IF=0] Gülden Diniz. et al. Tissue Expression of Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Breast Cancers.. European Journal of Breast Health. 2022 Oct;18(4):336-342  IHC ;  Human.  
研究領域 細胞生物  免疫學  細胞膜受體  細菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse,Rat (predicted: Pig,Cow,Dog)
產品應用 WB=1:500-2000,Flow-Cyt=1ug/test,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HAVCR1: 51-150/359 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Function:
May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair.

Subcellular Location:
Membrane; Single-pass type I membrane protein (Probable).

Tissue Specificity:
Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.

Similarity:
Belongs to the immunoglobulin superfamily. TIM family. Contains 1 Ig-like V-type (immunoglobulin-like)

SWISS:
Q96D42

Gene ID:
26762

Database links:

Entrez Gene: 26762 Human

Entrez Gene: 171283 Mouse

Entrez Gene: 286934 Rat

Omim: 606518 Human

SwissProt: Q96D42 Human

SwissProt: Q5QNS5 Mouse

SwissProt: O54947 Rat

Unigene: 129711 Human

Unigene: 17771 Mouse

Unigene: 11154 Rat



產品圖片
Sample: Lane 1: Mouse Testis tissue lysates Lane 2: Mouse Cerebrum tissue lysates Lane 3: Mouse Thymus tissue lysates Lane 4: Rat Testis tissue lysates Lane 5: Rat Cerebrum tissue lysates Lane 6: Rat Thymus tissue lysates Lane 7: Human A549 cell lysates Lane 8: Human A431 cell lysates Primary: Anti-HAVCR1 (bs-2713R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kDa Observed band size: 50 kDa
Blank control: A549. Primary Antibody (green line): Rabbit Anti-HAVCR1c antibody (bs-2713R) Dilution: 3μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-PE Dilution: 3μg /test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
Blank control:HepG2. Primary Antibody (green line): Rabbit Anti-HAVCR1c/TIM 1 antibody (bs-2713R) Dilution: 1ug/Test; Secondary Antibody (white blue line) : Goat anti-rabbit IgG-AF488 Dilution: 0.5ug/Test. Isotype control(orange line):Normal Rabbit IgG Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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