| 產(chǎn)品編號 | bs-5162R |
| 英文名稱 | Rabbit Anti-AADACL1 antibody |
| 中文名稱 | 中性膽固醇酯水解酶1抗體 |
| 別 名 | Arylacetamide deacetylase like 1; Arylacetamide deacetylase-like 1; Kiaa1363; NCEH; Nceh1; NCEH1_HUMAN; Neutral cholesterol ester hydrolase 1; Neutral cholesterol ester hydrolase. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 腫瘤細(xì)胞生物標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 46kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AADACL1: 151-250/408 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The assembly of very-low-density lipoproteins (VLDLs) in the secretory apparatus of the hepatocyte relies on the mobilization of triacylglycerol (TAG) from the cytosolic pool by lipolysis and re-esterification. However, some of the re-esterified TAG products are returned to the cytosolic pool in the liver, which protects vulnerable body tissues from excess lipotoxic non-esterified fatty acids in the plasma. Some of the lipases involved in this process include arylacetamide deacetylase (AADAC) and its related proteins AADACL1 and AADACL2. AADAC, a single pass type II membrane protein of the endoplasmic reticulum, is expressed in hepatocytes, intestinal mucosal cells, pancreas and adrenal gland. It plays an important role in the metabolic activation of arylamine substrates to ultimate carcinogens. AADACL1 hydrolyzes the metabolic intermediate 2-acetyl monoalkylglycerol, and its inactivation results in disruption of ether lipid metabolism in cancer cells and impaired cell migration and tumor growth. Function: Hydrolyzes 2-acetyl monoalkylglycerol ether, thepenultimate precursor of the pathway for de novo synthesis ofplatelet-activating factor. May be responsible for cholesterolester hydrolysis in macrophages, thereby contributing to thedevelopment of atherosclerosis. Also involved in organdetoxification by hydrolyzing exogenous organophosphorus compounds.May contribute to cancer pathogenesis by promoting tumor cellmigration. Subcellular Location: Membrane; Single-pass type II membraneprotein (Probable). Microsome Tissue Specificity: Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines. Post-translational modifications: N-glycosylated. Similarity: Belongs to the 'GDXG' lipolytic enzyme family. SWISS: Q6PIU2 Gene ID: 57552 Database links: Entrez Gene: 57552 Human Entrez Gene: 320024 Mouse Omim: 613234 Human SwissProt: Q6PIU2 Human SwissProt: Q8BLF1 Mouse Unigene: 444099 Human Unigene: 24576 Mouse |
