| 產(chǎn)品編號 | bs-4608R |
| 英文名稱 | Rabbit Anti-CUEDC2 antibody |
| 中文名稱 | CUE結(jié)構(gòu)域蛋白2抗體 |
| 別 名 | bA18I14.5; C10orf66; Chromosome 10 open reading frame 66; CUE domain containing 2; CUE domain-containing protein 2; CUED2; CUED2_HUMAN; Cuedc2; MGC2491; OTTHUMP00000020368. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶 表觀遺傳學(xué) 泛素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 32kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CUE domain containing 2: 201-287/287 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Function: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. Subunit: Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors. DISEASE: Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression. Similarity: Belongs to the CUEDC2 family. Contains 1 CUE domain. SWISS: Q9H467 Gene ID: 79004 Database links: Entrez Gene: 79004 Human Entrez Gene: 67116 Mouse Omim: 614142 Human SwissProt: Q9H467 Human SwissProt: Q9CXX9 Mouse Unigene: 500874 Human Unigene: 218848 Mouse Unigene: 19673 Rat CUEDC2(CUE Domain Containing 2)能夠結(jié)合IKKα和IKKβ,并通過使IKKα和IKKβ去磷酸化而抑制NF-κ信號通路。CUEDC2能特異性結(jié)合雌激素受體（ER），并導(dǎo)致ER的泛素化降解.抑制乳腺癌細(xì)胞的生長。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (mouse lung tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CUEDC2) Polyclonal Antibody, Unconjugated (bs-4608R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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