| 產(chǎn)品編號(hào) | bs-13534R |
| 英文名稱 | Rabbit Anti-GPR37 antibody |
| 中文名稱 | G蛋白偶聯(lián)受體37/帕金森相關(guān)內(nèi)皮素受體樣受體抗體 |
| 別 名 | GPCR GPR37; EDNRBL; Endothelin B receptor like protein 1; Endothelin B receptor-like protein 1; Endothelin receptor type B like; ETBR LP 1; ETBR-LP-1; ETBRLP1; G protein coupled receptor 37; G protein coupled receptor 37 endothelin receptor type B like; Gpr37; GPR37_HUMAN; hET(B)R LP; hET(B)RLP; PAELR; Parkin associated endothelin receptor like receptor; Parkin-associated endothelin receptor-like receptor; Probable G protein coupled receptor 37; Probable G-protein coupled receptor 37; GPCR 37. |
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Specific References (3) | bs-13534R has been referenced in 3 publications.
[IF=2.586] Kai Kitamura. et al. Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ. TISSUE CELL. 2023 Jun;82:102093 IF ; Mouse.
[IF=1.105] Aimi FUYUKI. et al. Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei. J VET MED SCI. 2023 Mar 01 IHC ; Mouse.
[IF=1.049] Sonjoy SARKAR. et al. Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system. 2020 Nov 18 WB,IHC ; Mouse.
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| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Rat (predicted: Mouse,Rabbit) |
| 產(chǎn)品應(yīng)用 | ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 67kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR37: 201-300/613 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Pael receptor (Pael-R), also known as Parkin-associated endothelin receptor-like receptor, is a putative G protein-coupled transmembrane polypeptide. The gene that encodes Pael-R maps to chromosome 7q31. Pael-R belongs to family 1 of the G protein-coupled receptors and is mainly expressed in the brain. Pael-R interacts with Parkin, the gene product responsible for familial Parkinson’s disease. Function: Orphan receptor. May have a unique functional role in the central nervous system. Subunit: Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG. Subcellular Location: Cell membrane. Endoplasmic reticulum membrane. Tissue Specificity: Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ). Post-translational modifications: Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death. DISEASE: Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ). Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: O15354 Gene ID: 2861 Database links: Entrez Gene: 2861 Human Entrez Gene: 14763 Mouse Omim: 602583 Human SwissProt: O15354 Human SwissProt: Q9QY42 Mouse Unigene: 731392 Human Unigene: 409670 Mouse Unigene: 28035 Rat |
