| 產(chǎn)品編號 | bs-20083R |
| 英文名稱 | Rabbit Anti-GPR106 antibody |
| 中文名稱 | G蛋白偶聯(lián)受體106抗體 |
| 別 名 | G protein coupled receptor 106; G-protein coupled receptor 106; G protein coupled receptor affecting testicular descent; GPR106; GPR-106; GREAT; INSL3R; Leucine rich repeat containing G protein coupled receptor 8; LGR8; Relaxin/insulin-like family peptide receptor 2; Relaxin family peptide receptor 2; Relaxin receptor 2; Relaxin receptor-2; RXFP 2; RXFP-2; RXFP2; RXFPR2; RXFP2_HUMAN; GPCR LGR8. |
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Specific References (1) | bs-20083R has been referenced in 1 publications.
[IF=7.267] Pan?Z et al. Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization. Gigascience. 2018 Apr 1;7(4). WB ; Sheep.
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| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞膜受體 內(nèi)分泌病 G蛋白偶聯(lián)受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 86kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR106: 301-400/754 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]. Function: The activity of this relaxin receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP and may also be a receptor for Leydig insulin-like peptide. LGR8 has been reported in blood, bone marrow, brain, kidney, muscle, testis, thyroid, and uterus. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow. DISEASE: Defects in RXFP2 are a cause of cryptorchidism (CRYPTO) [MIM:219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. Similarity: Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 10 LRR (leucine-rich) repeats. SWISS: Q8WXD0 Gene ID: 122042 Database links: Entrez Gene: 122042 Human Entrez Gene: 140498 Mouse Omim: 606655 Human SwissProt: Q8WXD0 Human SwissProt: Q91ZZ5 Mouse Unigene: 680763 Human Unigene: 444643 Mouse |
| 產(chǎn)品圖片 |
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-GPR106 Polyclonal Antibody, Unconjugated(bs-20083R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-GPR106 Polyclonal Antibody, Unconjugated(bs-20083R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: rat kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-GPR106 Polyclonal Antibody, Unconjugated(bs-20083R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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