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Rabbit Anti-ZNF127  antibody (bs-7149R)  
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產(chǎn)品編號 bs-7149R
英文名稱 Rabbit Anti-ZNF127  antibody
中文名稱 鋅指蛋白127抗體
別    名 D15S9; Makorin ring finger protein 3; Mkrn3; MKRN3_HUMAN; Probable E3 ubiquitin-protein ligase makorin-3; RING finger protein 63; RNF63; ZFP127; Zinc finger protein 127; ZNF127.  
研究領域 轉錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig)
產(chǎn)品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 57kDa
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZNF127: 361-460/507 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq, Jul 2008]

Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Tissue Specificity:
Expressed in testis, brain, heart and kidney. Ubiquitously detected at low levels throughout the entire embryo, but expression is highest in the ventricular layers of the brain.

DISEASE:
Expressed at the blastocyst stage and the embryonic days 8-17, as well as in undifferentiated and differentiated embryonic stem cells. Expressed in the arcuate nucleus of both male and female animals. Levels of expression are highest on postnatal days 10 and 12, begin to decline on day 15, and reaches a nadir by days 18 to 22, at which time expression is 10 to 20% of the levels detected at 10 days. The timing of the decline in protein expression correlated with the ages at which arcuate KISS1 and TAC2 have been shown to increase, heralding the onset of puberty.

Similarity:
Contains 3 C3H1-type zinc fingers.
Contains 1 RING-type zinc finger.

SWISS:
Q13064

Gene ID:
7681

Database links:

Entrez Gene: 7681 Human

Entrez Gene: 22652 Mouse

Entrez Gene: 292988 Rat

Omim: 603856 Human

SwissProt: Q13064 Human

SwissProt: Q60764 Mouse

Unigene: 679587 Human

Unigene: 72964 Human

Unigene: 146 Mouse



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