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Rabbit Anti-MRC1  antibody (bs-23178R)  
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產(chǎn)品編號 bs-23178R
英文名稱 Rabbit Anti-MRC1  antibody
中文名稱 巨噬細(xì)胞甘露糖受體 (CD206) 抗體
別    名 Mannose Receptor; C-type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor; Mannose receptor C type 1; MMR; MRC 1; MRC-1; MRC1_HUMAN; Macrophage mannose receptor 1; MRC1L1; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1.  
Specific References  (2)     |     bs-23178R has been referenced in 2 publications.
[IF=15.881] Yale Yue. et al. Biomimetic Nanoparticles Carrying a Repolarization Agent of Tumor-Associated Macrophages for Remodeling of the Inflammatory Microenvironment Following Photothermal Therapy. Acs Nano. 2021;XXXX(XXX):XXX-XXX  FC ;  mouse.  
[IF=4.2] Li Li. et al. Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway. BIOTECHNOL GENET ENG. 2023 Apr 26  WB ;  Mouse.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞膜受體  糖蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Rat (predicted: Mouse,Rabbit)
產(chǎn)品應(yīng)用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 160kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Macrophage mannose receptor 1: 1231-1292/1292 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region. [provided by RefSeq]

Function:
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.

Subcellular Location:
Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.

Similarity:
Contains 8 C-type lectin domains.
Contains 1 fibronectin type-II domain.
Contains 1 ricin B-type lectin domain.

SWISS:
P22897

Gene ID:
4360

Database links:

Entrez Gene: 4360 Human

Entrez Gene: 17533 Mouse

Entrez Gene: 291327 Rat

Omim: 153618 Human

SwissProt: P22897 Human

SwissProt: Q61830 Mouse

Unigene: 75182 Human

Unigene: 2019 Mouse



巨噬細(xì)胞甘露糖受體,主要存在于巨噬細(xì)胞膜表面的模式識別受體,能夠特異性識別甘露糖、巖藻糖或N-乙酰葡糖胺,介導(dǎo)巨噬細(xì)胞吞噬抗原,啟動免疫反應(yīng).
產(chǎn)品圖片
Sample: Liver (Rat) Lysate at 40 ug Primary: Anti-Macrophage mannose receptor 1 (bs-23178R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 160 kD Observed band size: 160 kD
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