| 產(chǎn)品編號 | bsm-33272M |
| 英文名稱 | Alpha-actinin-1 Mouse mAb |
| 中文名稱 | α-輔肌動蛋白1單克隆抗體 |
| 別 名 | ACTN 1; ACTN1_HUMAN; alpha Actinin 1; alpha actinin cytoskeletal isoform; alpha-actinin cytoskeletal isoform; alpha-actinin-1; FLJ40884; FLJ54432; Actinin alpha 1; F-Actin Cross-Linking Protein; Non-Muscle alpha-Actinin-1; Actinin, alpha 1; Actinin 1 Smooth Muscle; BDPLT15; |
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Specific References (1) | bsm-33272M has been referenced in 1 publications.
[IF=5.5] Chen, Yejia. et al. Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis. THROMB J. 2022 Dec;20(1):1-14 WB ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 發(fā)育生物學(xué) 細(xì)胞骨架 |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號 | 6A10 |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:500-1000,IF=1:500-1000,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 103 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human Alpha-actinin-1 protein 1-205/894 (C-6x His-Tag) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Subunit: Homodimer; antiparallel. Interacts with DDN, MYOZ2, PDLIM2, TTID and LPP. Interacts with PSD. Interacts with MICALL2 (By similarity). Interacts with DNM2 and CTTN (By similarity). Subcellular Location: Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Cell membrane. Cell junction. Cell projection ? ruffle. Similarity: Belongs to the alpha-actinin family. Contains 1 actin-binding domain. Contains 2 CH (calponin-homology) domains. Contains 2 EF-hand domains. Contains 4 spectrin repeats. SWISS: P12814 Gene ID: 87 Database links:
Entrez Gene: 87 Human Entrez Gene: 109711 Mouse Omim: 102575 Human SwissProt: P12814 Human SwissProt: Q7TPR4 Mouse Unigene: 509765 Human Unigene: 253564 Mouse Unigene: 403477 Mouse Unigene: 6401 Rat |
