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Mouse Anti-human CD38/FITC antibody (bsm-30080M-FITC)  
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說(shuō)明書: 50T  
50T/1880.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bsm-30080M-FITC
英文名稱 Mouse Anti-human CD38/FITC antibody
中文名稱 FITC標(biāo)記人CD38單克隆抗體
別    名 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38_HUMAN.  FITC anti-human CD38;
研究領(lǐng)域 腫瘤  免疫學(xué)  干細(xì)胞  糖尿病  細(xì)胞表面分子  糖蛋白  淋巴細(xì)胞  t-淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來(lái)源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) HIT2
交叉反應(yīng)
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 34kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
亞    型 IgG1
純化方法 affinity purified by Protein G
緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Function:
Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Subcellular Location:
Membrane; Single-pass type II membrane protein.

Tissue Specificity:
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

Similarity:
Belongs to the ADP-ribosyl cyclase family.

SWISS:
P28907

Gene ID:
952

Database links:

Entrez Gene: 952 Human

Omim: 107270 Human

SwissProt: P28907 Human

Unigene: 479214 Human



產(chǎn)品圖片
Flow cytometry staining of normal human peripheral blood cells with CD38/FITC(bsm-30080M-FITC)(Red histogram) or Mouse IgG2a Isotype Control (FITC Conjugate)(C03-12001)(Blue histogram) . Total cells were used for analysis.
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