產(chǎn)品編號 | bsm-51715M |
英文名稱 | Mouse Anti-MIR16 antibody |
中文名稱 | 膜蛋白相互作用蛋白GDE1 (MIR16)單克隆抗體 |
別 名 | GDE1; GDE1_HUMAN; EC 3.1.4.44; Glycerophosphodiester phosphodiesterase 1; Glycerophosphoinositol glycerophosphodiesterase GDE1; Membrane interacting protein of RGS16; Membrane-interacting protein of RGS16; RGS16 interacting membrane protein; RGS16-interacting membrane protein; Lysophospholipase D GDE1. |
研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 糖蛋白 |
抗體來源 | Mouse |
克隆類型 | Monoclonal |
克 隆 號 | E10F6 |
交叉反應(yīng) | Human |
產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理論分子量 | 38kDa |
細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | Recombinant humans GDE1. |
亞 型 | IgG1,Κ |
純化方法 | affinity purified by Protein G |
緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
產(chǎn)品介紹 |
GDE1 is a 331 amino acid multi-pass membrane protein that localizes to both the membrane and the cytoplasm and contains one GDPD domain. Expressed in a wide variety of tissues, GDE1 uses magnesium as a cofactor to catalyze the conversion of 1-(sn-glycero-3-phospho)-1D-myo-inositol to myo-inositol and sn-glycerol 3-phosphate, an event that is modulated by G protein signaling pathways and provides a link between phosphoinositide metabolism and G protein signal transduction. The gene encoding GDE1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. Function: MIR6 has glycerophosphoinositol phosphodiesterase activity. Subunit: Interacts with RGS16. Interacts with PRAF2. Subcellular Location: Cytoplasmic. Membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed. Post-translational modifications: N-glycosylated Similarity: Belongs to the glycerophosphoryl diester phosphodiesterase family. Contains 1 GDPD domain. SWISS: Q9NZC3 Gene ID: 51573 Database links: Entrez Gene: 51573 Human Omim: 605943 Human SwissProt: Q9NZC3 Human Unigene: 512607 Human |
產(chǎn)品圖片 | |