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Mouse Anti-MIR16  antibody (bsm-51715M)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bsm-51715M
英文名稱 Mouse Anti-MIR16  antibody
中文名稱 膜蛋白相互作用蛋白GDE1 (MIR16)單克隆抗體
別    名 GDE1; GDE1_HUMAN; EC 3.1.4.44; Glycerophosphodiester phosphodiesterase 1; Glycerophosphoinositol glycerophosphodiesterase GDE1; Membrane interacting protein of RGS16; Membrane-interacting protein of RGS16; RGS16 interacting membrane protein; RGS16-interacting membrane protein; Lysophospholipase D GDE1.  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  糖蛋白  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 E10F6
交叉反應(yīng) Human
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 38kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant humans GDE1. 
亞    型 IgG1,Κ
純化方法 affinity purified by Protein G
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 GDE1 is a 331 amino acid multi-pass membrane protein that localizes to both the membrane and the cytoplasm and contains one GDPD domain. Expressed in a wide variety of tissues, GDE1 uses magnesium as a cofactor to catalyze the conversion of 1-(sn-glycero-3-phospho)-1D-myo-inositol to myo-inositol and sn-glycerol 3-phosphate, an event that is modulated by G protein signaling pathways and provides a link between phosphoinositide metabolism and G protein signal transduction. The gene encoding GDE1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Function:
MIR6 has glycerophosphoinositol phosphodiesterase activity.

Subunit:
Interacts with RGS16. Interacts with PRAF2.

Subcellular Location:
Cytoplasmic. Membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
N-glycosylated

Similarity:
Belongs to the glycerophosphoryl diester phosphodiesterase family.
Contains 1 GDPD domain.

SWISS:
Q9NZC3

Gene ID:
51573

Database links:

Entrez Gene: 51573 Human

Omim: 605943 Human

SwissProt: Q9NZC3 Human

Unigene: 512607 Human



產(chǎn)品圖片
Sample: Lane 1: Human brain tissue lysates Primary: Anti-MIR16 (bsm-51715M) at 1/2000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 38 kD Observed band size: 38 kD
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