| 產(chǎn)品編號 |
bs-1310R-HRP |
| 英文名稱1 |
Rabbit Anti-Integrin Alpha V + Beta 3 (CD51+CD61)/HRP Conjugated antibody
|
| 中文名稱 |
辣根過氧化物酶標記的整合素αVβ3抗體 |
| 別 名 |
CD51 + CD61; CD51; CD61; GP3A; GPIIIa; integrin alpha v; integrin beta 3; intregrin alpha v beta 3; ITGAV; ITGB3; Platelet membrane glycoprotein IIIa; Vitronectin receptor alpha subunit; VNRA; Antigen identified by monoclonal antibody L230; CD51 antigen; CD61 antigen; DKFZp686A08142; Integrin alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin alpha v; Integrin beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin beta chain beta 3; intregrin alpha v beta 3; ITGAV; MSK8; Platelet glycoprotein IIIa; Platelet membrane glycoprotein IIIa; Vitronectin receptor alpha subunit; Vitronectin receptor subunit alpha. |
| 規(guī)格價格 |
100ul/2980元
購買 大包裝/詢價 |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
細胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 干細胞 細胞粘附分子 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Human, Mouse, Rat,
|
| 產(chǎn)品應(yīng)用 |
WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 3 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. They are known to participate in cell adhesion as well as cell-surface mediated signalling. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.
CD51 encodes integrin alpha chain V. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. The CD61 protein product is the integrin beta chain beta 3. Integrin beta 3 is found along with the alpha IIb chain in platelets.
Integrin alpha V/beta 3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha V/beta 3 recognizes the sequence R-G-D in a wide array of ligands. The alpha V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands.
Subcellular Location:
Cell Membrane; single-pass type I membrane protein.
Database links:
Entrez Gene: 3685 Human
Entrez Gene: 3690 Human
Omim: 173470 Human
Omim: 193210 Human
SwissProt: P05106 Human
SwissProt: P06756 Human
Unigene: 218040 Human
Unigene: 436873 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
整合素αVβ3為二聚體的跨膜糖蛋白質(zhì)，可以調(diào)節(jié)腫瘤細胞在多種細胞外基質(zhì)蛋白中的粘附和遷移，在被激活的內(nèi)皮細胞中有較高的表達，并在新生血管生成過程中發(fā)揮優(yōu)勢。
整合素αVβ3在細胞外的信號傳入細胞內(nèi)調(diào)節(jié)細胞生長、改變細胞形態(tài)、影響細胞運動, 并在腫瘤侵襲和轉(zhuǎn)移的過程中起重要作用.整合素αVβ3是特異性表達在血管內(nèi)皮細胞表面的粘附因子。
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