mm1313亚洲精品,欧美俄罗斯40老熟妇,欧美日韩在线观看视频在线,亚洲欧美国产激情综合在线

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  人才招聘  關(guān)于我們  聯(lián)系我們
国产精品偷伦视频免费观看了,精品久久久久中文字幕,人人添人人澡人人爽亚洲av
Rabbit Anti-VCP/BF488 Conjugated antibody (bs-1443R-BF488)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@www.p2b3.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@www.p2b3.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1443R-BF488
英文名稱1 Rabbit Anti-VCP/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的含纈酪肽蛋白抗體
別    名 valosin-containing protein; 15S Mg(2+) ATPase p97 subunit; ATPase p97; IBMPFD; MGC131997; MGC148092; MGC8560; p97; TER ATPase; TERA; transitional endoplasmic reticulum ATPase; valosin-containing protein; VCP; yeast Cdc48p homolog; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit; p97.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  糖尿病  糖蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 97kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VCP
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]

Function:
Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Regulates E3 ubiquitin-protein ligase activity of RNF19A.

Subcellular Location:
Cytoplasm > cytosol. Nucleus. Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.

Post-translational modifications:
Phosphorylated by tyrosine kinases in response to T-cell antigen receptor activation (By similarity).
Phosphorylated upon DNA damage, probably by ATM or ATR. ISGylated.

DISEASE:
Defects in VCP are the cause of inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD) [MIM:167320]; also known as muscular dystrophy, limb-girdle, with Paget disease of bone or pagetoid amyotrophic lateral sclerosis or pagetoid neuroskeletal syndrome or lower motor neuron degeneration with Paget-like bone disease. IBMPFD features adult-onset proximal and distal muscle weakness (clinically resembling limb girdle muscular dystrophy), early-onset Paget disease of bone in most cases and premature frontotemporal dementia.

Similarity:
Belongs to the AAA ATPase family.

Database links:

Entrez Gene: 7415 Human

Entrez Gene: 269523 Mouse

Entrez Gene: 116643 Rat

Omim: 601023 Human

SwissProt: P55072 Human

SwissProt: Q01853 Mouse

SwissProt: P46462 Rat

Unigene: 529782 Human

Unigene: 245976 Mouse

Unigene: 98891 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

含纈酪肽蛋白(VCP即p97),是一種廣泛存在的膜結(jié)合糖蛋白,在細(xì)胞活性中有著廣泛的功能,其特點(diǎn)是作為類似分子伴侶的作用在內(nèi)質(zhì)網(wǎng)相關(guān)的蛋白降解及細(xì)胞周期調(diào)控中起到重要作用,VCP蛋白可以和肝素在細(xì)胞表面結(jié)合,而起到保護(hù)細(xì)胞的作用。
目前對(duì)VCP的表達(dá)水平與食道癌、胃癌、結(jié)、直腸癌、肝癌、胰腺癌等消化系統(tǒng)惡性腫瘤等是研究的熱點(diǎn)。
版權(quán)所有 2004-2026 www.www.p2b3.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
旅游| 贺州市| 红河县| 凉城县| 饶平县| 安阳县| 云南省| 宜宾市| 横峰县| 九寨沟县| 潮州市| 迁安市| 东乡族自治县| 舒兰市| 桃源县| 陇南市| 宜昌市| 长治市| 乌拉特后旗| 大竹县| 华阴市| 崇义县| 台山市| 民乐县| 西吉县| 鲁甸县| 堆龙德庆县| 大城县| 丰宁| 阳城县| 子长县| 综艺| 东乡族自治县| 吉木萨尔县| 安泽县| 蒙城县| 昆明市| 钟山县| 津南区| 南漳县| 五河县|