| 產(chǎn)品編號(hào) | bs-6757R-BF594 |
| 英文名稱1 | Rabbit Anti-BCA2/ZNF364/BF594 Conjugated antibody |
| 中文名稱 | BF594標(biāo)記的乳腺癌相關(guān)基因2抗體（鋅指蛋白364） |
| 別 名 | BCA2; Breast cancer associated gene 2; CL469780; Rabring 7; RING finger protein 115; RNF115; Zinc finger protein 364; ZNF364; ZNF 364; RN115_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 細(xì)胞類型標(biāo)志物 腫瘤細(xì)胞生物標(biāo)志物 鋅指蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZNF364/BCA2/RNF115 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The RING finger family of proteins possess ubiquitin ligase activity and play pivotal roles in protein degradation and receptor-mediated endocytosis. The autoubiquitination activity of ZNF364 indicates that it is a novel RING-type E3 ligase. Its effects on cell growth indicate that ZNF364 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth. Function: Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking. Subunit: Interacts with RAB7A. Subcellular Location: Cytoplasm, cytosol (By similarity). Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes (By similarity). Tissue Specificity: Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells. Post-translational modifications: RING-type zinc finger-dependent and E2-dependent autoubiquitination. Similarity: Contains 1 RING-type zinc finger. Database links: Entrez Gene: 101060478 Human Entrez Gene: 27246 Human Entrez Gene: 67845 Mouse SwissProt: Q9Y4L5 Human SwissProt: Q9D0C1 Mouse Unigene: 523550 Human Unigene: 386792 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
