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Rabbit Anti-NCX2/Gold Conjugated antibody (bs-1997R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1997R-Gold
英文名稱1 Rabbit Anti-NCX2/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的鈉鈣交換蛋白2抗體
別    名 SLC8A2; Sodium/calcium exchanger 2; solute carrier family 8 (sodium/calcium exchanger), member 2; Na(+)/Ca(2+)-exchange protein 2; Na+/Ca2+ exchanger 2; sodium/calcium exchanger 2 precursor; Slc8a2; NAC2_HUMAN; SLC8A2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  交換蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 98kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NCX2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.

Function:
Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.
Contains 2 Calx-beta domains.

Database links:
UniProtKB/Swiss-Prot: Q9UPR5.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

鈉鈣交換蛋白又稱鈉鈣交換體,有三種同分異構(gòu)體,即NCX1、NCX2和NCX3。2型Na-Ca交換蛋白-NCX2, 很多組織中都有表達,分布與胞漿及胞膜。
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