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Rabbit Anti-CD30/PE-Cy7 Conjugated antibody (bs-2495R-PE-Cy7)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-2495R-PE-Cy7
英文名稱(chēng)1 Rabbit Anti-CD30/PE-Cy7 Conjugated antibody
中文名稱(chēng) PE-Cy7標(biāo)記的CD30抗體
別    名 CD 30; CD30; CD30 antigen; CD30L receptor; Cytokine receptor CD30; D1S166E; KI 1; Ki 1 antigen; Ki-1 antigen; KI1; Lymphocyte activation antigen CD30; TNFRSF 8; TNFRSF8; TNFRSF8; TNR8_HUMAN; Tumor Necrosis Factor Receptor Superfamily Member 8; Tumor Necrosis Factor Receptor Superfamily Member 8.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  細(xì)胞類(lèi)型標(biāo)志物  腫瘤細(xì)胞生物標(biāo)志物  細(xì)胞因子  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Pig,  (predicted: Rabbit, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD30
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Function:
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.

Subunit:
Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.

Subcellular Location:
Isoform Long: Cell membrane; Single-pass type I membrane protein.
Isoform Short: Cytoplasm.

Post-translational modifications:
Phosphorylated on serine and tyrosine residues.

Similarity:
Contains 6 TNFR-Cys repeats.

Database links:

Entrez Gene: 943 Human

Omim: 153243 Human

SwissProt: P28908 Human

Unigene: 1314 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD30是一種單鏈糖蛋白,標(biāo)記活化T和B淋巴細(xì)胞,R-S細(xì)胞和部分淋巴濾泡間區(qū)免疫母細(xì)胞。CD30是霍奇金淋巴瘤的一個(gè)特異性標(biāo)記,也是大細(xì)胞間變型淋巴瘤的診斷型標(biāo)志。
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