| 產(chǎn)品編號(hào) | bs-2646R-PE |
| 英文名稱 | Rabbit Anti-LAG-3/PE Conjugated antibody |
| 中文名稱 | PE標(biāo)記的淋巴細(xì)胞活化基因-3抗體 |
| 別 名 | Lymphocyte activation gene 3; CD223; FDC protein; LAG 3; LAG3; Lymphocyte activation gene 3 protein; LAG3_HUMAN. |
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Journal
PMID
IF
Application
[IF=3.64] Parodi, Alessia, et al. "CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes." Cancer Immunology, Immunotherapy (2013): 1-12. IF ; Human.
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| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 自然殺傷細(xì)胞 t-淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LAG-3 C-terminus |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Lymphocyte-activation protein 3 (LAG-3), also known as CD223, belongs to the immunoglobulin superfamily and contains 4 extracellular Ig-like domains. LAG-3 binds to HLA class-II antigens and is involved in lymphocyte activation. It is found on the cell surface of activated NK and T-lymphocytes. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG-3 to CD4. Function: Involved in lymphocyte activation. Binds to HLA class-II antigens (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: On cell surface of activated NK and T-lymphocytes. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: UniProtKB/Swiss-Prot: P18627.5 Entrez Gene: 3902 Human Omim: 153337 Human SwissProt: P18627 Human Unigene: 409523 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
