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Rabbit Anti-Myeloperoxidase/PE-Cy5 Conjugated antibody (bs-1061R-PE-Cy5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1061R-PE-Cy5
英文名稱1 Rabbit Anti-Myeloperoxidase/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的髓過氧化物酶抗體
別    名 Myeloperoxidase; MPO; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  激酶和磷酸酶  淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Dog, Cow, Horse, Rabbit, Guinea Pig, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Myeloperoxidase
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008].

Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Subunit:
Tetramer of two light chains and two heavy chains.

Subcellular Location:
Lysosome.

DISEASE:
Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.

Similarity:
Belongs to the peroxidase family. XPO subfamily.

Database links:

Entrez Gene: 4353 Human

Entrez Gene: 17523 Mouse

Entrez Gene: 303413 Rat

Omim: 606989 Human

SwissProt: P05164 Human

SwissProt: P11247 Mouse

Unigene: 458272 Human

Unigene: 4668 Mouse

Unigene: 47782 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

髓過氧化物酶MPO,作為一種白細胞酶,具有介導炎性反應、調(diào)節(jié)免疫應答等多種功能,并可參與疾病的發(fā)生發(fā)展過程。同時,髓過氧化物酶基因存在基因多態(tài)性,也影響機體對疾病的易感性. 在正常淋巴組織中和各種髓樣細胞增生癥中,MPO均有較強表達,如:淋巴樣細胞、原核細胞、肥大細胞、漿細胞以及各種上皮源性腫瘤和肉瘤等。
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