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Rabbit Anti-Macrophage mannose receptor 1/Gold Conjugated antibody (bs-4727R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-4727R-Gold
英文名稱1 Rabbit Anti-Macrophage mannose receptor 1/Gold Conjugated antibody
中文名稱 膠體金標記的巨噬細胞甘露糖受體抗體
別    名 Mannose Receptor; Macrophage mannose receptor 1; C-type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor 1; Macrophage mannose receptor; Mannose receptor C type 1; MMR; MRC 1; MRC-1; OTTHUMP00000045206; MRC1_HUMAN; MRC1; MRC1L1; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細胞生物  免疫學  轉(zhuǎn)錄調(diào)節(jié)因子  細胞膜受體  糖蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 160kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MRC1/CD206
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region. [provided by RefSeq].

Function:
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.

Subcellular Location:
Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.

Similarity:
Contains 8 C-type lectin domains.
Contains 1 fibronectin type-II domain.
[SIMILARITY] Contains 1 ricin B-type lectin domain.

Database links:

Entrez Gene: 4360 Human

Entrez Gene: 17533 Mouse

Entrez Gene: 291327 Rat

Omim: 153618 Human

SwissProt: P22897 Human

SwissProt: Q61830 Mouse

Unigene: 75182 Human

Unigene: 2019 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

巨噬細胞甘露糖受體,主要存在于巨噬細胞膜表面的模式識別受體,能夠特異性識別甘露糖、巖藻糖或N-乙酰葡糖胺,介導巨噬細胞吞噬抗原,啟動免疫反應.
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