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Rabbit Anti-FLT3L/AP Conjugated antibody (bs-10170R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-10170R-AP
英文名稱1 Rabbit Anti-FLT3L/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的FMS樣酪氨酸激酶3配體抗體
別    名 Flt 3 ligand; Flt 3L; Flt3 L; FLT3 LG; Flt3 ligand; Flt3L; FLT3L_HUMAN; FLT3LG; Fms related tyrosine kinase 3 ligand; Fms-related tyrosine kinase 3 ligand; SL cytokine.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 心血管  細(xì)胞生物  干細(xì)胞  細(xì)胞分化  淋巴細(xì)胞  t-淋巴細(xì)胞  b-淋巴細(xì)胞  細(xì)胞因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FLT3L
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Flt 3 ligand (Flt 3-L), variously designated Flt 3/Flk 2 ligand or FL, is a hematopoietic growth factor that stimulates the proliferation of stem and CD34+ progenitor cells and has been cloned from both mouse and human genomes. Flt 3-L is a potent in vitro growth stimulator of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and G-CSF-dependent granulocyte-macrophage committed precursors from Lin CD34+ bone marrow cells as well as other primitive B cell populations. Additionally, Flt 3-L stimulates the proliferation of hematopoietic progenitor cells isolated from mouse fetal liver or adult mouse bone marrow. Flt 3-L does not, however, affect the growth of erythroid-committed progenitors. Flt 3-L exists in two forms and is active as both a soluble and as a membrane-bound ligand. The Flt 3-L receptor, Flt 3, is a tyrosine kinase expressed on CD34+ cells that shares a high degree of homology with the SCF (stem cell factor) receptor, c-Kit and c-Fms.

Function:
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

Subunit:
Homodimer (isoform 2).

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Database links:

Entrez Gene: 2323 Human

Entrez Gene: 719239 Rhesus monkey

Omim: 600007 Human

SwissProt: P49771 Human

Unigene: 428 Human





Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Flt3L是一種可以促進(jìn)多種干細(xì)胞、血細(xì)胞及其前體細(xì)胞生成、分化的細(xì)胞因子,對T淋巴細(xì)胞、B淋巴細(xì)胞和NK細(xì)胞和DC的前體細(xì)胞都有促進(jìn)增生、誘導(dǎo)分化的功能.Flt3L可與其它促細(xì)胞生長的細(xì)胞因子有很好的協(xié)同作用.目前,尚未發(fā)現(xiàn)具有毒性作用,是一種良好的擴(kuò)增劑,對研究細(xì)胞的形態(tài)、細(xì)胞表現(xiàn)型和功能具有重要的意義.
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