| 產(chǎn)品編號(hào) |
bs-19463R-APC |
| 英文名稱 |
Rabbit Anti-PSMC3/APC Conjugated antibody
|
| 中文名稱 |
APC標(biāo)記的蛋白酶體26S亞基ATP酶3抗體 |
| 別 名 |
26S protease regulatory subunit 6A;
26S proteasome AAA-ATPase subunit RPT5;
Human immunodeficiency virus tat transactivator binding protein 1;
MGC8487;
Proteasome (prosome macropain) 26S subunit ATPase 3;
Proteasome 26S ATPase subunit 3;
Proteasome 26S subunit ATPase 3;
Proteasome subunit P50;
PRS6A_HUMAN;
PSMC 3;
PSMC3;
Tat binding protein 1;
TAT-binding protein 1;
TBP-1;
TBP1. |
| 規(guī)格價(jià)格 |
100ul/2980元
購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 |
100ul
|
| 研究領(lǐng)域 |
細(xì)胞生物 結(jié)合蛋白 泛素 |
| 抗體來(lái)源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Human, Mouse,
(predicted: Dog, Cow, Horse, Xenopus laevis)
|
| 產(chǎn)品應(yīng)用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
49kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human PSMC3 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
Function:
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.
Subcellular Location:
Cytoplasm. Nucleus.
Post-translational modifications:
Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
Similarity:
Belongs to the AAA ATPase family.
Database links:
Entrez Gene: 5702 Human
Entrez Gene: 19182 Mouse
Entrez Gene: 29677 Rat
Entrez Gene: 379370 Xenopus laevis
Omim: 186852 Human
SwissProt: P17980 Human
SwissProt: O88685 Mouse
SwissProt: Q63569 Rat
SwissProt: O42586 Xenopus laevis
Unigene: 250758 Human
Unigene: 289832 Mouse
Unigene: 11173 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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