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Rabbit Anti-TRAP 5/Gold Conjugated antibody (bs-12788R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-12788R-Gold
英文名稱1 Rabbit Anti-TRAP 5/Gold Conjugated antibody
中文名稱 膠體金標記的酒石酸酸性磷酸酶5型抗體
別    名 TRAP5; Acid phosphatase 5, tartrate resistant; ACP5; EC 3.1.3.2; phosphatase, acid, type 5, tartrate-resistant; PPA5_HUMAN; serum band 5 tartrate-resistant acid phosphatase; SPENCDI; Tartrate-resistant acid ATPase; Tartrate-resistant acid phosphatase type 5; TR-AP; TRACP 5; TRAcP; TRAP; TrATPase; Type 5 acid phosphatase.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  激酶和磷酸酶  淋巴細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35, 42kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRAP 5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]

Function:
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

Subcellular Location:
Lysosome.

DISEASE:
Defects in ACP5 are the cause of spondyloenchondrodysplasia with immune dysregulation (SPENCDI) [MIM:607944]. A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. Note=ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease.

Similarity:
Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

Database links:

Entrez Gene: 54 Human

Entrez Gene: 11433 Mouse

Entrez Gene: 25732 Rat

Omim: 171640 Human

SwissProt: P13686 Human

SwissProt: Q05117 Mouse

SwissProt: P29288 Rat

Unigene: 1211 Human

Unigene: 46354 Mouse

Unigene: 171928 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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